Molecular Formula | C19H15N3O3S2 |
Molar Mass | 397.47 |
Solubility | DMSO: soluble |
Appearance | Yellow solid |
Storage Condition | −20°C |
Sensitive | Light Sensitive |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
biological activity | AG-825 is a selective, ATP-competitive ErbB2 inhibitor that inhibits tyrosine phosphorylation, and its IC50 value is 0.35 μM. AG-825 has anti-cancer activity. AG825 can significantly accelerate the apoptosis of human neutrophils. AG-825 is a potential drug to overcome manganese-induced neurotoxicity or the development of Alzheimer's disease. |
target | ErbB2 0.35 μM (IC 50 ) EGFR 19 μM (IC 50 ) |